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pentobarbital decreases effects of sufentanil SL by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Watch Carefully. Coadministration of CYP3A4 inducers may decrease sufentanil levels and efficacy, maybe precipitating withdrawal syndrome in sufferers who've made physical dependence to sufentanil. Discontinuation of concomitant

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